Effect of exercise training on ethanol-induced oxidative damage in aged rats

Abstract It is well known that lipid peroxidation increases with age, and alcohol drinking further exacerbates this damage. The present study determined the effect of regular exercise training on alcohol-induced oxidative damage and antioxidant status in the liver of aged animals. The age-matched Wistar albino rats (3 months young, n  = 24; 18 months old, n  = 24) were evenly divided into four groups: control (C), exercise trained (Ex), ethanol drinking (Et), and exercise plus ethanol drinking (Ex + Et). With ethanol drinking, hepatic malondialdehyde (MDA) level was significantly elevated above control ( P