Doppler echocardiographic evaluation of left ventricular diastolic function in acute hypothyroidism

Summary OBJECTIVE Left ventricular diastolic dysfunction Is an important cause of symptomatic heart failure. Previous studies suggest that thyroid dysfunction affects left ventricular diastolic function but the underlying mechanisms remain controversial. The study was undertaken to assess the influence of acute hypothyroidism on left ventricular diastolic function and to elucidate possible underlying mechanisms by means of Doppler echocardiography in a group of athyreotic patients, whose thyroid state depended only on external thyroid hormone supply and could therefore easily be controlled. PATIENTS Eleven patients (5 men, 6 women, aged 20-55 years), who had had total thyroidectomy, were investigated during mild hyperthyroidism and during acute hypothyroidism. Additionally, 11 healthy control subjects aged 25-51 years were included in the study. DESIGN M-mode echocardiography of the left ventricle and pulsed-wave Doppler echocardiography of the trans-mitral flow velocity pattern were carried out. RESULTS Acute hypothyroidism produced a decrease of left ventricular end-diastolic diameter from 48 ± 5 to 46 ± 5 mm (mean ± SD P < 0.05), of peak velocity of early diastolic filling from 0.52 ± 0.10 to 0.42 ± 0.05 m/s (P < 0.05), of peak velocity of late diastolic filling from 0.42 ± 0.10 to 0.36 ± 0.09 m/s (P < 0.05), and a decreased time-velocity integral of early diastolic filling (6 2 ± 1 8 vs 5.1 ± 0.7 cm, P < 0.05). The other M-mode and Doppler echocardiographic parameters did not differ between the hyperthyroid and the hypothyroid states. CONCLUSIONS The observed changes of the transmitral flow velocity pattern during acute hypothyroidism can be attributed to a reduction of pre-load. There is no direct evidence that acute hypothyroidism affects the intrinsic diastolic properties of the left ventricle.