For inducing pluripotent stem cell compositions and their use
2011
The present invention provides a specific order to import the Sendai virus vector encoding for induced pluripotent stem cell reprogramming factor genes; containing these vectors for use in the induction of pluripotent stem cells in gene composition, and their use. By KLF gene, OCT gene, as well as SOX gene in a certain order group into a Sendai virus vector succeeded in increasing the pluripotent stem cell induction efficiency. By mounting a plurality of reprogramming factors to a carrier, so as to reduce the necessary number of carriers, to further improve the pluripotent stem cell induction efficiency becomes possible.
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