Toxicities induced by CMF chemotherapy in Rabbits

Chemotherapeutic agents are used for the treatment of cancer. These cytotoxic agents produce hematological & hepatic toxicities. This study is aimed to assess the toxicities induced by CMF (Cyclophosphamide Methotrexate and 5-fluro – uracil) on liver and kidney. The study was conducted on female rabbits. The animals were grouped into four groups. One group was treated with CMF. The second group was treated with Tamoxifen. The third group was treated with CMF and Tamoxifen where as the fourth group was not treated with any drug and considered as control. The rabbits treated with CMF and Tamoxifen have shown increased level of AST and ALT as compared to control rabbits and the rabbits that received six CMF cycles. Lactate dehydrogenase (LDH) was also increased in CMF and Tamoxifen treated rabbits as compared to control rabbits. The histopathological changes in CMF and Tamoxifen treated rabbits had shown liver oedema, portal infiltration and fibrosis, where as kidney mesangial cell proliferation was (71.4%) also observed in rabbits treated with CMF & Tamoxifen