ADHESION PREVENTION EFFECTS OF TOLMETIN COMBINED WITH HYALURONIC ACID

This study was to investigate the effects of intra-sheath injection of tolmetin sodium plus sodium hyaluronate (Tolmetin-HA) on adhesion formation in chicken flexor tendon model. Seventy-five chickens were divided into three groups. The long flexor tendon of central digit of all chickens was incised and sutured with a modified Kessler stitch. Tolmetin-HA (0.1% of tolmetin sodium and 1% of HA in PBS) or HA (1% HA in PBS) or saline was applied to each group respectively by injecting 0.2ml into intra-sheath space near the conclusion of the surgical procedure. The chickens were executed 2 weeks after the operation. The extent of adhesion formation in each chicken was evaluated grossly and histologically. The results indicated that tolmetin-HA significantly reduced the extent and severity of post-surgical tendon adhesion in comparison with HA or saline (P<0.01). HA showed a beneficial tendency in preventing adhesion, but the difference was not significant in comparison with saline.