Expression changes of P2X_3 receptor units in dorsal root ganglion neurons after sciatic nerve injury in rats

Objective To investigate expression changes of P2X3 receptor of dorsal root ganglion neurons after sciatic nerve injury at different time points in rat.Methods Upon transected sciatic nerve in the adult rats,expression changes of P2X3 receptor were studied in control,operation(2d) and operation(7d) group respectively through immunohistochemistry.Results Immunohistochemistry showed that 31.73%,35.26% and 42.93% of DRG neurons were P2X3 receptor-positive neurons in control,operation(2d) and operation(7d) group,respectively.Conclusion P2X3 receptor of DRG neurons is involved in nerve injury.