A multiplex immunofluorescence assay to assess immune checkpoint inhibitor-targeted CD8 activation and tumor colocalization in FFPE tissues.

Tony Navas,Kristin Fino,King Leung Fung,Facundo Cutuli,Robert J. Kinders,Aditi Sharma,Geraldine O’Sullivan Coyne,Alice P. Chen,Toby Tucker Hecht,James H. Doroshow,Ralph E. Parchment

A multiplex immunofluorescence assay to assess immune checkpoint inhibitor-targeted CD8 activation and tumor colocalization in FFPE tissues.

2019

Tony Navas
Kristin Fino
King Leung Fung
Facundo Cutuli
Robert J. Kinders
Aditi Sharma
Geraldine O’Sullivan Coyne
Alice P. Chen
Toby Tucker Hecht
James H. Doroshow
Ralph E. Parchment

2629Background: Immune checkpoint inhibitors promote antitumor immune responses by enhancing T-cell activity. Measuring the pharmacodynamic effects of these drugs is challenging, as it requires ass...

Keywords:

Colocalization
Multiplex
CD8
Pathology
Cancer research
Immunofluorescence
Immune checkpoint
Medicine
Immune system
immune checkpoint inhibitors

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