"Procedure for obtaining derivatives (2-alkyl-3-pyridyl) methylpiperazine".

Herein DESCRIBED PROCESS FOR THE PREPARATION OF DERIVATIVES (2-alkyl-3-pyridyl) methylpiperazine GENERAL FORMULA I, WHERE IS RBS1 -CN, -COSI2 (CSI1-CSI6) alkyl, -C = CR3 ; RBS2 is hydrogen or (CSI1-CSI6) ALKYL GROUP YR ES (RBS4RBS5RBS6) CXZ-, PHSI2C = NOCHSI2- O RBS8RBS9C = CH-, wherein Z is single bond, O CHSI2 CHSI2CHSI2 (optionally substituted); X is a single bond, O, NRBS7 (rbs7 is hydrogen, alkyl, alkylcarbonyl) OS (= 0) SIN (N ES 0,1,2); When X is a single bond RBS4, RBS5 AND RBS6 are hydrogen, (CSI1CSI6) alkyl, (CSI1CSI6) alkoxycarbonyl, phenyl AND EITHER can also be halogen, amino or hydroxy; For other definitions of X, RBS4, RBS5 AND RBS6 are hydrogen, (CSI1-CSI6) -alkyl, or phenyl, or if X is NH two of them can form a carbonyl group; RBS8 And RBS9 are phenyl or CFSI3; CHARACTERIZED IN THAT IS A COMPOUND II, where P is an amine protecting O RCO group, with a base to give a compound III, DONDEP ES RCO (in which case III IS I), or alternatively P is a protecting group Amina, IN WHICH CASE deprotected to give the amine IV, WHICH reacted with an acid RCOOH OR EQUIVALENT acylating reagent, to give a compound I. Such compounds are PAF antagonists AND, THEREFORE, useful in the treatment of diseases in WHICH that substance is involved. FORMULA