FEBUXOSTAT ATTENUATES CARDIAC ISCHEMIA REPERFUSION INJURY BY MODULATING MAPK/NF- KAPPA B/TNF-ALPHA PATHWAY

Objective:Reperfusion of an occluded coronary artery results in injury to the myocardium, known as ischemia reperfusion (IR) injury. Xanthine oxidase (XO) and myeloperoxidase are one of the key regulators implicated in this injury. Therefore, the effect of febuxostat (FEB) and allopurinol (ALL) was