Nanoliposome-microbubble assemblies encapsulating complex of Cas9 protein, guide RNA for repressing gene expression or SRD5A2 gene and cationic polymer, and composition comprising the same for improving or treating hair loss

The present invention relates to a nanoliposome-microbubble conjugate encapsulating a composite of a cationic polymer, a guide RNA inhibiting expression of a SRD5A2 gene, and a Cas9 protein, and a composition for improving or treating hair loss containing the same. Drugs currently used as hair loss treatments may cause serious side effects such as loss of libido or erectile dysfunction, and hair loss can proceed again if drug therapy is discontinued. However, by using the nanoliposome-microbubble conjugate of the present invention, it is possible to fundamentally inhibit SRD5A2 which induces hair loss, and treatment of hair loss in men can be conducted very effectively.