Formulation and In-Vitro Characterization of Nimorazole Mouth Dissolving Tablets

Nimorazole is an antimicrobial with activity against anaerobic bacteria and protozoa. Its actions and properties are similar to Nimorazole.easily absorbed from the GI tract. Peak plasma levels within 2 hr. As precision of dosing and patient compliance become important prerequisite for quick relief from motion sickness, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while traveling and better compliance. Hence in the present research work mouth dissolving tablets of Nimorazole were developed with Superdisintegrants like Crospovidone, Indion 414, L . HPC and Pregelatinised starch in various concentrations like 8 % and 10 % w/w by wet granulation method. All formulations were evaluated for physical characteristics of compressed tablets such as weight variation, hardness, friability, drug content, disintegration time and in vitro dissolution study. Among all, the formulation F4 (containing 10% w/w concentration of Crospovidone) was considered to be the best formulation, having disintegration time of 27 sec, hardness 2.56 kg/cm2 and in vitro drug release of 92.23% in 15 min. All the formulation follows Higuchi order release kinetics.