Synthesis of 4-Amino-Thiazole Analogs of Fmoc-Amino Acids and Thiazole Linked N-Orthogonally Protected Dipeptidomimetics

We report a one pot synthesis of Fmoc amino acid derived 4-amino-thiazole derivatives and thiazole linked Northogonally protected dipeptidomimetics by the condensation of Nα-Fmoc α-halomethylketones with thiourea and Boc/Z-α-amino acid thioamides via modified Hantzch protocol. Side chain modified Fmoc amino acids containing 4- amino thiazole moiety have also been synthesized following the similar protocol.