Does Estradiol Level in Platelet-Rich Plasma Improve Efficacy of Androgenic Alopecia Treatment?

BACKGROUND Although there are some studies in the literature reporting that autologous and homologous platelet-rich plasma (PRP) can be used in treatment of androgenic alopecia (AGA), there is no study examines estrogen concentration of prepared PRP. OBJECTIVE We aimed to determine the presence of estrogen in PRP and to investigate the effect of estrogen concentration of PRP on AGA treatment, in this study. METHODS Between 2017-2018, 30 male patients with hair loss complaints were included in this prospective study. Autologous PRP was injected to patients in Group 1. Homologous PRP with high estrogen levels was injected to the patients in Group 2. PRP injected to both groups 4 times in 0, 1st, 3rd, and 6th months. The obtained photographs were evaluated and hair densities of each patient at controls were calculated. RESULTS The mean estrogen level measured in PRP was statistically significantly higher in Group 2. In both groups, the increase in hair density was observed from the first month, but this increase was statistically significantly higher in all controls in Group 2. In Group 2, there was a statistically significant increase in the 1st and 3rd months compared with the previous control, but there was no difference between the 6th and 12th months and the 3rd month. CONCLUSIONS It has been determined that increase in hair density is higher and earlier in the group use estrogen-rich PRP than the group use autologous. We think that estrogen-rich PRP may be used in the treatment of AGA in the presence of an appropriate donor.