A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
2005
We examined the coding sequence of 518 protein kinases, similar to 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
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