Abstract 10919: Contemporary Life Expectancy and Standardized Mortality of Adult Survivors With Congenital Heart Lesions

Background: Survival beyond the age of 18 years in patients born with congenital heart disease (CHD) is now near 90% but contemporary estimates of outcome in adult survivors are lacking. Methods: In a prospective cohort of 3,334 adults with CHD followed up to 24 years in a single tertiary centre median age of survival (MAS) was estimated by computing left-truncated and right-censored Kaplan-Meier curves with age as time scale. Standardized mortality ratio (SMR) was also determined using one-sample log-rank test from age at diagnosis-, sex- and time of follow-up-adjusted death rates of general population in Spain. Patients were classified into 3 groups according to CHD complexity: I, simple (1,647); II, moderate (1,283); and III, severe (404). For mortality analysis, data provided by the Spanish national death index were used. Results: There were 1,688 males and 1,646 females. Median age at first examination was 22 years (IQR 18-39) and median follow-up time 10.6 years (1-18). At the end of the study 336 patients had died (prevalence 10%; annual incidence 0.89%). Estimated MAS was 78.0 years (95% CI 76-82) for group I; 72,1 years (68-78) for group II; and 51.1 years (48-53) for group III (p Conclusion: Life expectancy for CHD adults is reduced proportionally to complexity of the heart defect. Data for individual diagnostic categories might be used as a prognostic index.