A FACILE ONE-POT SYNTHESIS OF NOVEL 1,1 '-(ALKANEDIYL)BIS(5-OXO-3- ALKYL/ARALKYL/ARYL-1,2,3,4,5,6,7,8-OCTAHYDROQUINAZOLINES & THEIR ANTI-BACTERIAL ACTIVITIES

A facile onepot synthesis of novel 1,1'�(alkanediyl)bis(5�oxo�3�alkyl/aralkyl/aryl� 1,2,3,4,5,6,7,8�octahydroquinazolines) 3a-r has been devised by the cyclocondensation of bis� enaminones 2a-f with primary amine and formaldehyde. The structures of the products have been established by spectral and analytical data as 1, 1 '�(alkanediyl)bis(5�oxo�3�alkyl/ aralkyl/aryl�1,2,3,4,5,6,7,8�octahydroquinazolines) . Some of the compounds have been found to possess promising antibacterial properties.