Isolation of Streptomyces from the sediments of selected thermal springs of Northern Pakistan and its intrinsic susceptibility and resistance

This investigation aimed to examine the intrinsic antimicrobial susceptibility and resistance of Streptomyces species, isolated from the sediments of selected thermal springs located in northern Pakistan. Isolated species were subjected to morphological, physiological; biochemical and microscopic analyses. The isolates were examined for the consumption of various carbon sources, deprivation of complex compounds, susceptibility and resistance to antimicrobials and inhibitory compounds. The results indicated that all isolates demonstrated complete resistances to penicillin and ampicillin and weak resistance to Cotrimoxazole, Cephazolin, Deoxycline and Lincomycine. These isolates were moderately susceptible to Erythromycin, Cefaparazone, Cefapime, Amoxicillin and Cephradine while completely susceptible to Tetracycline, Vancomycin, Amikacin Gentamicin and Imipenem. In addition, Streptomyces isolates were more susceptible to Vancomycin and Gentamicin as compared to other antimicrobials and inhibitory compounds. This potential vulnerability of Streptomyces to Vancomycin and Gentamicin in particular, as therapeutic agents against infections by Streptomyces species is discussed.