Metabolism Drives Carcinogenesis and Maintenance of Pancreatic Tumors

Summary: In this issue of Cancer Discovery , Carrer and colleagues find that early events in pancreatic tumorigenesis are driven by altered acetyl-CoA metabolism, where targeting this axis in established cancer models impairs tumor growth. This work provides new insights into the roles of acetyl-CoA in pancreatic cancer and underscores the value of studying early events in carcinogenesis to yield new treatment strategies. See related article by Carrer et al., p. 416 .