A simplified method for isolation of the S-carboxymethyl derivative chains of normal fibrinogen and fibrinogen cleveland I

Abstract Highly purified individual chains of normal fibrinogen and fibrinogen Cleveland I were prepared by chromatographing the reduced, carboxymethylated whole protein upon columns of S-P Sephadex C-50. This method is suitable, as a preliminary step, in the further study of either normal or abnormal fibrinogen.