Angiogenesis and Immune Suppression in Cancer

Angiogenesis and immune suppression share common cellular and molecular mediators, and these processes are linked in diverse biological processes such as wound healing, pregnancy, and cancer. This shared program exists under physiological conditions and is co-opted under pathological conditions. Here, we focus on these connections in the context of tumor biology, emphasizing the role of vascular endothelial growth factor (VEGF) and that of the angiogenic tumor endothelium as an immune regulator.