Development of Hemostatic Agents

Abstract : To translate investigational hemostatic agents developed in the rat model to swine models of lethal groin injury and liver laceration. This objective evaluated the efficacy of patch and granule formulations of capsaicin (CP-305) in normal and coagulopathic swine models. The thermal stability of the dmg patches was studied at elevated temperatures to assess shelf life of the hemostatic agent. The remaining objectives were to study the mechanism of action of vanilloid compounds on whole blood aggregation and develop bio-degradable vanilloid compounds.