3′,4′ Dihydronorstephasubine, a new bisbenzylisoquinoline from the bark of Alseodaphne corneri

A new bisbenzylisoquinoline, 3',4'-dihydronorstephasubine (1) together with two known alkaloids, norstephasubine (2) and gyrolidine (3) were isolated from the stem bark of Alseodaphne corneri (Lauraceae). The 13 C-NMR data for norstephasubine (2) and gyrolidine (3) were also reported. Structural elucidation of 1 was performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRMS. 3',4'-Dihydronorstephasubine (1) and gyrolidine (3) showed moderate vasorelaxant effect on rat aorta.