5-Lipoxygenase and Leukotrienes Transgenic Mouse and Nuclear Targeting Studies

A decade has passed since the molecular cloning of the 5-lipoxygenase gene and nearly twenty years since the discovery of leukotrienes. In our laboratory, we have strived to make advances in the realm of basic biology and understanding of the 5-lipoxygenase/leukotriene pathway by the use of knockout mice and other cell biology techniques. The aim of this article is to survey the studies conducted with these mice and to present novel information about the nuclear localization of 5-lipoxygenase.