Immunological parameters and ultrastructure of blood formed elements in nephrotic syndrome in children

: The aim of the study was the evaluation of significance of immunopathogenic mechanisms in the pathogenesis of minimal change nephrotic syndrome and the study of the ultrastructural changes of peripheral blood formed elements. The observation was carried out on 64 patients with steroid sensitive minimal change nephrotic syndrome. During the manifestation and recurrence of the disease, in the majority of the patients, the results of immunological studies revealed the reduction in both total and absolute count of T-lymphocytes on the background of decreased immunoregulatory index (T(4+)/ T(8+)). In the peripheral blood statistically reliable reduction in the percent value of T(3+) and T(4+) phenotype lymphocytes and elevation of number of T(8+)-lymphocytes were observed. On the background of normal values of B-lymphocytes appeared increase of IgM and decrease of IgG and IgA. In most cases significant elevation in the value of IgE - (244+10,3) and low values of INF-gamma, ultrastructural changes of blood monocytes were apparent. The peculiarities of ultrastructural changes of eosinophils and basophiles especially were pronounced by cytomembrane degranulation in form of decrease in electric density.