Oligonucleotide Derivatives in Organism: Distribution Among Organs, Rates of Release and Degradation

O. M. Bazanova,Valentin V. Vlassov,V. F. Zarytova,E M Ivanov,E. A. Kuligina,L. A. Yakubov,M. N. Abdukayumov,V.N. Karamyshev,G Zon

Oligonucleotide Derivatives in Organism: Distribution Among Organs, Rates of Release and Degradation

1991

O. M. Bazanova
Valentin V. Vlassov
V. F. Zarytova
E M Ivanov
E. A. Kuligina
L. A. Yakubov
M. N. Abdukayumov
V.N. Karamyshev
G Zon

Abstract oligonucleotide derivatives were observed partially degraded in all tissues of mice 30 min post-injection. Conoentration in liver and kidney was 100-fold larger than in brain. Phosphorothioate oligos were more resistant than pho-sphodiesters.

Keywords:

Oligonucleotide
Organism
Biochemistry
Kidney
Biology
Molecular biology
Degradation (geology)
Chemistry
liver and kidney

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