EXCRETION OF URINARY ANDROGENS FOLLOWING THE INJECTION OF TESTOSTERONE PROPIONATE

THIS PAPER presents the results of 121 assays for urinary androgens in 16 cases of hypogonadism in men and in 6 normal men. The method employed for assay of the urine of the patients was that of Gallagher and Koch (1, 2), while in the normal group the method of McCullagh and McLin (3) was used. In each assay 5 birds were employed and 5 controls were injected with androsterone. The normal range lies between 18 and 90 i.u. per 24-hour specimen of urine. In normals, 22 assays by the 1st method average 39.3 u and 26 assays by the 2nd averaged 35.7 u. The probable error in the 1st group is 6.52 and in the 2nd is 5.03. Group 1. Testosterone propionate1 in doses varying from 5 to 50 mg. was given to hypogonadal individuals and the urinary androgens during the succeeding 24 hours were measured. Assays done in this group preceding treatment all gave findings below the normal range, the average being 4 u.