compositions, protein, polynucleotide, method of generating an immune response detection method, pharmaceutical composition, antibody, or fragment thereof transgenic animal hybridoma supply method of a cytotoxic agent or diagnostic agent and method of inhibiting cell growth cancer

"Compositions, protein, polynucleotide, METHOD OF GENERATION AN IMMUNE RESPONSE, DETECTION METHOD, PHARMACEUTICAL COMPOSITION, antibody or fragment thereof, transgenic animal, HYBRIDOMA, SUPPLY METHOD OF AN AGENT cytotoxic OR DIAGNOSIS AGENT AND GROWTH method of inhibiting CANCER CELLS ". They are described innovative 098P4B6 gene (also designated STEAP-2) and its encoded protein, and variants thereof, wherein 98P4B6 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers related in Table I. Consequently, 98P4B6 target provides diagnostic, prognostic, prophylactic and / or therapeutic for cancer. The 98P4B6 gene or fragment thereof, or its encoded protein, or variants thereof, or fragment thereof, can be used to provide humoral or cellular immune response; antibodies or T cells reactive with 98P4B6 can be used in active or passive immunization.