Racemic Descriptors for Quantitative Structure Activity Relationship of Spirosuccinimide Type Aldose Reductase Inhibitors

]pyrazine-1,3-dione derivatives acting as aldose reducta se inhibitors. While the spirosuccinimide compoundscontain a chiral center, the aldose reductase inhibition assay was performed with racemic mixtures in thepublished work. As the physicochemical descriptors of the QSAR analysis must be evaluated for a definitemolecular structure, we devise a new “racemic” descriptor as the arithmetic mean of the (