Haematological and miRNAs (let-7g, miR-21, miR-141) expression modulation profile in serum samples of Human prostate cancer

MicroRNAs represent a promising new class of biomarkers owing to their inherent stability and resilience. This study investigated the haematological and miRNA expression modulation profile in serum samples of human prostate cancer. Twenty-two study participants with age range between 59 and 82yeaars were included in the study after informed consent. Blood samples of the participant were obtained and both haematological parameters and miRNA analysis (miR-21, miR-141 and let-7g) were performed using Bc-3200 auto-haemalogical analyzer and RT-PCR. The result shows that there was no correlation between the haematological profile and the modulation of miR-21, miR-141 and let-7g. There was no significant difference in the haematological profile between the healthy control and prostate cancer (PCa) patients. However, miR-21, miR-141 and let-7g (p<0.0001) expressions were significantly up regulated although, miR-21 expression was more pronounced in the serum of the study participants relative to healthy control gr...