Palladium-Catalyzed Direct Amination of Allylic Alcohols at Room Temperature

The article describes palladium-catalyzed direct amination of allylic alcohols at room temperature. Simple palladium(II) complex has been identified to be an efficient catalyst for the direct amination of allylic alcohols with amines via C-O bond cleavage. This simple reaction can be performed at room temperature and can be used for synthesis of a broad range of linear allylamines, which are important for natural product synthesis and drug discovery. Considering the practical importance of this atom- and stepeconomical amination reaction, significant further applications are expected. Keywords: Allylic Alcohols; Allylic Amines; Chemical-Specific Hazards; Palladium-Catalyzed Amination; Pd(Xantphos)Cl2 Catalyst; Transition-Metal-Catalyzed Amination