Abstract 10892: Sumoylation of Copper Chaperone Atox1 via Cysteine Oxidation of SENP1 as a Key Switch to Promote Atox1 Nuclear Translocation Driving Inflammation and Atherosclerosis

Introduction: Copper (Cu), essential nutrient, plays a role in inflammation and atherosclerosis with unknown mechanism. In inflamed endothelial cells (ECs), Cu chaperone Atox1 functions as a Cu-dep...