One-Pot Synthesis of N-(Imidazo[1,2-a]pyridin-3-yl)-Substituted Sulfonamides Using Catalytic Zinc Chloride.

A one-pot two-step synthesis of N-(imidazo[1,2-a]pyridin-3-yl)sulfonamides from easily available arylglyoxal hydrates, 2-aminopyridines, and sulfonamides has been developed. The procedure, using zinc chloride as catalyst, is simple and inexpensive. The desired products were obtained in moderate to good yields under the optimized reaction conditions.