Biologische Festkörper-NMR-Spektroskopie in der Strukturbiologie

Biological solid-state NMR elucidates the structure and dynamics of biomolecules at physiological temperatures. It provides high-resolution structural information for a wide range of biomolecules and assemblies, from small membrane proteins embedded in a lipid environment, over fibrillar structures up to supramolecular assemblies. Recent developments allow for proton detection at fast magic angle spinning frequencies, which reduces the required sample amounts to a few hundreds of micrograms.