Synthesis of thromboxane B2 and prostaglandins by bovine gastric mucosal microsomes.

Abstract Bovine gastric mucosal microsomes synthesize prostaglandins from arachidonic acid but thromboxane B 2 is the principal product. Thromboxane B 2 synthesis occurs at an appreciable rate from endogenous precursor but more rapidly with added arachidonate. Nonsteroidal antiinflammatory drugs inhibited synthesis of prostaglandins and thromboxanes with the following decreasing order of potency: indomethacin, fenoprofen, acetylsalicylic acid, phenylbutazone, sulfinpyrazone, and acetaminophen.