Gelatinase B is associated with peri-implant bone loss.

2003 
Abstract: The aim of this study was to clear whether gelatinase B is associated with peri-implant bone loss (PBL). Peri-implant sulcus fluid was collected from 46 implant sites in 12 patients. These sites were also characterized using modified Gingival Index (mGI). Activated and total gelatinase B levels, measured using a modified urokinase assay, showed correlation with PBL (n=46, Spearman's rank correlation test). Activated and total gelatinase B values were significantly higher in PBL>3 mm group (n=6) compared to PBL 0.5 group (n=24) was clearly higher compared to mGI=0 (n=13) and p0.5 (n=9) groups (Rank sum test). We conclude that gelatinase B is associated with PBL. Activation of gelatinase B together with elevated mGI eventually reflect active phases of peri-implantitis and may prove to be diagnostically useful.
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