Incense Smoke Exposure: An Appraisal of Organ Toxicity

Background: This narrative type review aimed to address organ toxicity emanating from incense usage.Methods: An online search using the following MeSH terms “Incense smoke,”, “adverse effects,”“organotoxicity”, “oxidative stress” and “inflammation” was done to identify studies directly applicable toadverse effects of incense smoke exposure.Findings: Exposure to incense smoke demonstrated various toxicity changes in the kidney, testes, lungs,liver and heart. Renal effects included a decrease in oxidative stress markers GSH and CAT, increase inMDA, serum creatinine uric acid and blood urea nitrogen (BUN). Testicular toxicityrevealed significantdisturbances in spermatogenetic patterns, testicular atrophy, germinal aplasia, hypospermia and damage tothe basal seminiferous epithelia tissue. In the cardiac muscle, ultrastructural changes, increased oxidativestress, inflammation, and altered cardiac hypertrophic gene expression was noted. Thenegative impactof incense smoke emanating from free radical (ROS), lipid peroxidation and GSH destabilizes vascularhomeostasis and initiates ahyperinflammatory response, warranting the need to understand the conceptualbasis of the mode of action linked to incense exposure.Conclusion: We highlight that incense generates ROS which initiates lipid peroxidation through ATP energydepletion and reduction in the natural antioxidants. This subsequently triggers oxidative stress, inflammationand endothelial dysfunction resulting in organotoxicity