Pharmacokinetics and Disposition of Various Drug Loaded Liposomes
2012
Due to great efforts in past 45 years, several liposomal products including two liposomal vaccine products have been commercialized
and many more potential products are now under clinical trial stage. Although liposome has significantly reduced the toxicity of
the drugs with improved or maintained the efficacy, its further development has been limited by its instabilities during preparation and
storage, incompatibility with certain drugs, relative high cost of production and quality control as well as unspecified drug release time
and sites in vivo. In vivo behaviors of liposomal drugs highly depend on their physiochemical properties including lipid composition, particle
size, surface charge, surface modifications and the administrated dose as well as the route of administration. Based on the literature
reports from the past two decades, the current review provided an updated summary of the key factors in liposomal preparations for clinical
usage and its impact on the alternation of pharmacokinetic and disposition behaviors of drugs encapsulated in the liposome formulations.
Clinical applications of liposomal preparation in anti-tumor agents, anti-infective agents as well as the macromolecules have been
highlighted.
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