[Our experience with management of inherited thrombophilia during pregnancy: preliminary report].

UNLABELLED: The physiologic mechanism that results in the occurrence of premenstrual syndrome (PMS) is not well understood. OBJECTIVE: Effective treatment in premenstrual syndrome with vitex agnus castus--femicur N in adolescent girls. [corrected]. MATERIAL AND METHODS: We have investigated 45 adolescent girls 14-16 years old for a 3 years period from march 2009 to march 2011. The first group of 23 girls were prescribed Femicur N 4 mg once daily for 3 month--90 capsules per course. The second group of 22 girls were given 40 mg of the study drug (Femicur N) twice a day, from the 19th day of the first day of the cycle for 10 days 3 month as the dose is 60 capsules per course. RESULTS: Our investigation showed that therapy with VAC-Femicur N in adolescents suffering from PMS was effective and the results were good. From 45 girls 20 girls (44.4%) were without any complaints and 13 girls (28.8%) had reduction of all premenstrual symptoms. In both groups premenstrual mastodynia in 13 girls (28.8%) has disappeard and with 4 girls (8.8%) complaints were redused.