Diazepine compounds and diazocano as MC4 agonists

2009 
A compound of formula (I): ** ** Formula or salts and pharmaceutically acceptable solvates thereof, wherein: n is 0 or 1; R1 is (C1-C4) or Het1; R2 is phenyl or pyridyl, said phenyl or pyridyl optionally substituted with one to three substituents selected independently from halo, CN, (C1-C4) -alkoxy and (C1-C4), wherein alkyl groups (C1- C4) -alkoxy and (C1-C4) are optionally substituted with 1 to 3 fluorines; R3 is phenyl or pyridyl, said phenyl or pyridyl optionally substituted with one to three substituents selected independently from halo, CN, (C1-C4) -alkoxy and (C1-C4), wherein alkyl groups (C1- C4) -alkoxy and (C1-C4) are optionally substituted with 1 to 3 fluorines; either L is -CO- and R4 is (C1-C4) alkoxy- (C1-C4) alkyl- (C3-C6) alkyl, (C1-C2) alkyl- (C3-C6) alkyl (C1-C2) alkoxy- (C1-C4), -NH2, -NH (C1-C4) -N [(C1-C4)] 2 or Het2, in which the alkyl group (C1-C4) estaopcionalmente substituted with 1 to 3 fluorine atoms and in which -cycloalkyl (C3-C6) is opcionalmentesustituido with 1 to 3 fluorine atoms or alkyl groups (C1-C4); or L is -SO2- and R4 is (C1-C4); (C3-C6) alkyl, (C1-C2) alkyl- (C3-C6) alkyl, (C1-C2) alkoxy- (C1-C4), -NH2, -NH (C1-C4) - N [(C1-C4)] 2 or Het 2; Het1 is (i) a 6-membered ring containing one or two atoms of Ne, being either aromatic ring, or biencontiene 2 double bonds in the ring and a substituent> = O, the ring being optionally substituted with one to tressustituyentes selected independently halo, CN and (C1-C4); (Ii) an aromatic 6-membered ring containing one or 2 N atoms fused at the 3 y4, relative to the binding pyrrolidine ring, an aromatic 5-membered ring containing from one to tresatomos over N ; or (iii) tetrahydropyranyl; Het2 is (i) an aromatic 5-membered ring containing one or 2 N atoms and one O atom, S atom oatomo N plus optional, (ii) a saturated ring of 4 to 6 members containing one atom N; or (iii) a saturated 6-membered ring containing one O atom and optionally more N.
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