Value of Serum β-hCG in Pathogenesis of Pre-Eclampsia

Background: Pre-eclampsia is a pregnancy specific disorder responsible for maternal and foetal morbidity and mortality. The aim of the present study was to find out the association of serum level of maternal β-hCG in normal pregnancy and pre-eclampsia and its role in development of pre-eclampsia.  Methods: The prospective randomized controlled study was conducted on 50 cases of pre-eclampsia with singleton foetus and 50 normotensive singleton mothers in the third trimester of pregnancy. The paired samples of serum samples were estimated for β-hCG and results were analyzed statistically using SPSS 17.  Result: The serum level of maternal β-hCG was markedly raised in preeclampsia (18,087.42 ± 2,014.17 mIU/mL) in comparison to controlled (8,391.06 ± 1,909.64 mIU/mL) and parallel with the severity of pre-eclampsia.  Conclusion: The maternal serum level of β-hCG plays one of the important role in pathogenesis of pre-eclampsia and its severity. doi: http://dx.doi.org/10.4021/jcgo57w