Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

Tarjinder Singh,Timothy Poterba,David Curtis,Huda Akil,Mariam M. Al Eissa,Jack D. Barchas,Nicholas Bass,Tim B. Bigdeli,Gerome Breen,Evelyn J. Bromet,Peter F. Buckley,William E. Bunney,Jonas Bybjerg-Grauholm,William F Byerley,Sinéad B. Chapman,Wei J. Chen,Claire Churchhouse,Nicholas John Craddock,Charles Curtis,Caroline M Cusick,Lynn E. DeLisi,Sheila Dodge,Michael Escamilla,Saana Eskelinen,Ayman H. Fanous,Stephen V. Faraone,Alessia Fiorentino,Laurent C. Francioli,Stacey Gabriel,Diane Gage,Sarah A. Gagliano Taliun,Andrea Ganna,Giulio Genovese,David C Glahn,Jakob Grove,Mei-Hua Hall,Eija Hämäläinen,Henrike O. Heyne,Matti Holi,David M. Hougaard,Daniel P. Howrigan,Hailiang Huang,Hai-Gwo Hwu,René S. Kahn,Hyun Min Kang,Konrad J. Karczewski,George Kirov,James A. Knowles,Francis S. Lee,Douglas S. Lehrer,Francesco Lescai,Dolores Malaspina,Stephen R Marder,Steven A. McCarroll,Helena Medeiros,Lili Milani,Christopher P. Morley,Derek W. Morris,Preben Bo Mortensen,Richard M. Myers,Merete Nordentoft,Niamh L. OBrien,Ana Maria Olivares,Dost Öngür,Willem H. Ouwehand,Duncan S. Palmer,Tiina Paunio,Digby Quested,Mark Hyman Rapaport,Elliott Rees,Brandi Rollins,F. Kyle Satterstrom,Alan F. Schatzberg,Edward M. Scolnick,Laura J. Scott,Sally I. Sharp,Pamela Sklar,Jordan W. Smoller,Janet L. Sobell,Matthew Solomonson,Christine Stevens,Jaana Suvisaari,Grace Tiao,Stanley J. Watson,Nicholas A. Watts,Douglas Blackwood,Anders D. Børglum,Bruce M. Cohen,Aiden Corvin,Tõnu Esko,Nelson B. Freimer,Stephen J. Glatt,Christina M. Hultman,Andrew McQuillin,Aarno Palotie,Carlos N. Pato,Michele T. Pato,Ann E. Pulver,David St Clair,Ming T. Tsuang,Marquis P. Vawter,James T.R. Walters,Thomas Werge,Roel A. Ophoff,Patrick F. Sullivan,Michael John Owen,Michael Boehnke,Michael Conlon ODonovan,Benjamin M. Neale,Mark J. Daly

Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

2020

Tarjinder Singh
Timothy Poterba
David Curtis
Huda Akil
Mariam M. Al Eissa
Jack D. Barchas
Nicholas Bass
Tim B. Bigdeli
Gerome Breen
Evelyn J. Bromet
Peter F. Buckley
William E. Bunney
Jonas Bybjerg-Grauholm
William F Byerley
Sinéad B. Chapman
Wei J. Chen
Claire Churchhouse
Nicholas John Craddock
Charles Curtis
Caroline M Cusick
Lynn E. DeLisi
Sheila Dodge
Michael Escamilla
Saana Eskelinen
Ayman H. Fanous
Stephen V. Faraone
Alessia Fiorentino
Laurent C. Francioli
Stacey Gabriel
Diane Gage
Sarah A. Gagliano Taliun
Andrea Ganna
Giulio Genovese
David C Glahn
Jakob Grove
Mei-Hua Hall
Eija Hämäläinen
Henrike O. Heyne
Matti Holi
David M. Hougaard
Daniel P. Howrigan
Hailiang Huang
Hai-Gwo Hwu
René S. Kahn
Hyun Min Kang
Konrad J. Karczewski
George Kirov
James A. Knowles
Francis S. Lee
Douglas S. Lehrer
Francesco Lescai
Dolores Malaspina
Stephen R Marder
Steven A. McCarroll
Helena Medeiros
Lili Milani
Christopher P. Morley
Derek W. Morris
Preben Bo Mortensen
Richard M. Myers
Merete Nordentoft
Niamh L. OBrien
Ana Maria Olivares
Dost Öngür
Willem H. Ouwehand
Duncan S. Palmer
Tiina Paunio
Digby Quested
Mark Hyman Rapaport
Elliott Rees
Brandi Rollins
F. Kyle Satterstrom
Alan F. Schatzberg
Edward M. Scolnick
Laura J. Scott
Sally I. Sharp
Pamela Sklar
Jordan W. Smoller
Janet L. Sobell
Matthew Solomonson
Christine Stevens
Jaana Suvisaari
Grace Tiao
Stanley J. Watson
Nicholas A. Watts
Douglas Blackwood
Anders D. Børglum
Bruce M. Cohen
Aiden Corvin
Tõnu Esko
Nelson B. Freimer
Stephen J. Glatt
Christina M. Hultman
Andrew McQuillin
Aarno Palotie
Carlos N. Pato
Michele T. Pato
Ann E. Pulver
David St Clair
Ming T. Tsuang
Marquis P. Vawter
James T.R. Walters
Thomas Werge
Roel A. Ophoff
Patrick F. Sullivan
Michael John Owen
Michael Boehnke
Michael Conlon ODonovan
Benjamin M. Neale
Mark J. Daly

By meta-analyzing the whole-exomes of 24,248 cases and 97,322 controls, we implicate ultra-rare coding variants (URVs) in ten genes as conferring substantial risk for schizophrenia (odds ratios 3 - 50, P

Keywords:

Genetics
Odds ratio
Gene
Coding (social sciences)
Schizophrenia
Biology
Exome sequencing

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