The preparation of the Fluorouracil Gemini surfactant noisome and the in vitro release behavior

Objective: To study the influence of Gemini surfactant noisome on the encapsulation function for the water soluble Fluorouracil and the in vitro release behavior so as to develop new carrier material.Methods: The non-ionic surfactant noisome was prepared by thin film hydration-ultrasonic method,with non-ionic Gemini surfactant,span60 and cholesterol as capsule wall material,water soluble anti-cancer drug Fluorouracil as model drug.And the optimal prescription was obtained by measuring the zeta potential,size,size distribution and encapsulation efficiency.And the release behavior of the Fluorouracil encapsulated in the Gemini surfactant noisome in simulated gastric and intestinal was studied by using the dissolution test system.Results: The encapsulation efficiency and the particle size distribution of the noisome were significantly improved by gemini surfactant.And the optimal prescription was as follows: Gemini 80 nmol,Span60 65 nmol,CHOL58 nmol,concentration of Fluorouracil 1 mg/ml and Hydration volume 20 ml.The in vitro release study indicated that the loaded Gemini surfactant noisome showed a good sustained release trend.Conclusion: Gemini surfactant can be used as a good kind of wall material for sustained release preparation,which shows a good application prospect for the Gemini surfactant.