Serum Levels Of Osteoprotegerin in Women with Subclinical Hypothyroidism Before and After Of Levothyroxine Treatment

Background: Osteoprotegrin (OPG) is a cytokine from tumor necrosis factor (TNF) super family and is classified as an inhibitory factor of osteoclast reproduction. There are evidences showing the regulatory action of OPG on bone turnover. Also the meaningful relationship of OPG levels and thyroid hormones levels has been shown. But the direct influence of hypothyroidism treatment on OPG levels is still a field of challenge. In this study we aimed to assess the potent effect of hypothyroidism treatment by levothyroxine on OPG levels of subclinical hypothyroidism in women before and after of using this drug. Methods: 50 women with ages ranging 20 to 45 were enrolled in this study in two 25 member group (case and control). The levels of OPG were measured in control group and case group for two times( before and after 2 months treatment by levothyroxine) Results: Although there was no difference between control and case groups before and after the treatment, the levels of OPG decreased notably in case group after treatment in comparison to before the treatment. Also, there was no significant correlation between OPG levels and other parameters in control group and patients before and after the treatment. Conclusion: Considering to therapeutic actions of levothyroxin, it is interesting that it can somehow have diverse effects on bone metabolism by altering OPG levels in hypothyroidism females.