Treatment of chronic hepatitis C in haemophilic patients

Patients with severe or moderate haemophilia A or B (n = 30) have been treated in our centre by using on demand therapy regimen (Immunate, Immunine, Fanhdi). The majority of older patients have been suffering from HCV due to using plasma non-inactivated products before 1990. We evaluate the results of treatment in eight patients with CHC, who were treated from 1999–2007. Only patients with positive PCR-HCV, verified progression of liver function tests (ALT, AST) and with given consent were treated. Primary infection was asymptomatic and has been unrecognised for many years. HCV genotyping was also performed – type Ia in three, type Ib in five cases were confirmed. No coinfection with HBV or HIV was observed.