Efficient Synthesis of 1,3,5-Trisubstituted Benzenes via Three Pd-Mediated Carbon—Sulfur, Carbon—Nitrogen and Carbon—Carbon Bond Formation Reactions.

Abstract An efficient synthesis of 1,3,5-trisubstituted benzenes via a sequential Pd-mediated carbon–sulfur, carbon–nitrogen, and carbon–carbon bond formation reactions is reported. Selective amidation and sulfonamidation reactions are accomplished via Pd-catalyzed reactions between aryl chlorides and an acetamide or a methanesulfonamide.