Role Of Alkalinization In Enhancing Efficacy Of The Local Anesthetic - A Clinical Study

Local anesthetics are the safest and most effective drugs employed for analgesia and pain management.Ways to improve the clinical efficacy of local anesthetics, particularly lignocaine, is a subject of extensive research and debate. Raising the pH of the lignocaine solution prior to its use has been a popular choice and has received considerable attention where soft-tissue surgery is performed. Hence, an attempt is made in this study to compare in vivo and ex vivo alkalinization and evaluate the efficacy of sodium bicarbonate in creating a favorable environment for lignocaine to act around the inflamed and infected pulpal and periapical tissues of the mandibular teeth for painless exodontia. alternative to depending upon the body in accomplishing an equivalent pH change after the injection of local anesthesia. The ex vivo process (buffered LA) uses the same chemical mechanism and molecule (bicarbonate) as the body will use to buffer the anesthetic after the injection in vivo (inside the body), but the ex vivo process is an innovative way to a c c o m p l i s h t h e p H c h a n g e (1) instantaneously and more dependably. The latency varies widely from patient to patient. Eliminating this variability and increasing predictability of onset, is a paramount feature of buffering anesthetic solutions outside the body. The presentstudy compares in vivo and ex vivo alkalinization and evaluates the efficacy of sodium bicarbonate in creating a favorable environment for lignocaine to act around the inflamed and infected pulpal and periapical tissues of the mandibular teeth for painless exodontia.