Research of Boletus Aereus on Effect of Lowering Hyperlipidemia and Antioxidation in Rats

Objective:To study the effect of Boletus aereus to lowering blood lipid and antioxidation in the hyper-lipidemia rats.Methods:The male SD rats were divided randomly into four groups,i.e.,high-dosage group,low-dosage group,hyperlipidemia model group and control group.High-dosage group,low-dosage group and hyper-lipidemia model group were fed on high lipid feed and were given with1ml/100g weight of6.50%,3.25%Boletus aereus and distilled water by stomach perfusion for thirty days,respectively.Then the blood lipid and antioxidation were tested.Results:The serum level of total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),triglyceride(TG)and malondialdehyde(MDA)in the high and low-dosage group were significantly lower(P0.01)than that in the hyperlipidemia model group and the serum level of high density lipoprotein cholesterol(HDL-C)and activities of superoxide dismutase(SOD)in serum and liver were significantly higher(P0.01)than that in the hyperlipidemia model group.Conclusion:Boletus aereus has a distinct effect of lowering the blood lipid and antioxidation in rats.