Synthesis method of 1,2-morpholine hydrochloride

2015 
The invention discloses a preparation method of 1,2-morpholine hydrochloride and mainly aims to solve the technical problems that the yield is low, the quality is unstable, the operation is complex and the like in an existing synthesis process. N-benzyl-hydroxylamine hydrochloride and 1,4-dibromobutane which serve as raw materials, sodium hydride serving as an alkali and tetrahydrofuran serving as a solvent have a reaction for 12 hours at the room temperature, then N-benzyl-1,2-cyclohydroxylamine is prepared, and 1,2-morpholine hydrochloride is prepared through palladium catalysis and hydrogenation debenzylation. The reaction formula is shown in the specification. The 1,2-morpholine hydrochloride is a useful intermediate or product for synthesis of multiple medicines.
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