Synthesis of 1-(2-Hydroxy-5-methylphenyl)phenethylamine

In this paper, p-tolyl phenylacetate was prepared from the reaction of 4-methylphenol and phenylacetyl chloride. 2-Hydroxy-5-methylphenyl benzyl actone was obstained through a rearrangement reaction using AlCl 3 as catalyst. Then hydroxy was methylated by Me 2SO 4 under PTC conditions. Then 2-methoxy-5-methylphenyl benzyl actone was aminated by HCO 2NH 4, and 1-(2-methoxy-5-methylphenyl)phenethylamine was obstained. At last, 1-(2-hydroxy-5-methylphenyl)phenethylamine was obstained by hydrosis reaction using hydrobromide. The structures of intermediate were confirmed by IR,element analysis and 1HNMR spectra.