A subset of five human mitochondrial formyl peptides mimics bacterial peptides and functionally deactivates human neutrophils

BACKGROUNDTrauma causes inflammation by releasing mitochondria that act as Danger-Associated Molecular Patterns (DAMPs). Trauma also increases susceptibility to infection. Human mitochondria contain 13 N-formyl peptides (mtFPs). We studied whether mtFPs released into plasma by clinical injury induce